Access to contraceptives supports family planning and saves lives through healthy birth spacing and the prevention of unintended pregnancies. Yet modern contraceptives remain out of reach for millions of women. Sayana® Press is a new formulation and presentation of the injectable contraceptive Depo-Provera® manufactured by Pfizer. Packaged in the Uniject™ injection system, Sayana® Press is simple for health workers to learn and administer—and it cannot be reused, eliminating the risk of transmitting infection. This innovation has the potential to greatly expand access to a safe, effective, reversible, and discreet contraceptive method.